Dr. Masakazu Toi graduated in 1982 from Hiroshima University School of Medicine with his Medical Doctorate and in 1988 with his Ph.D. He studied on tumor angiogenesis at the Institute of Molecular Medicine of Oxford University, UK from 1990 to 1992. He was appointed to the Department of Clinical Oncology, John-Radcliffe Hospital of Oxford University as an academic visitor as well. From 1992 to 2007, Dr. Toi worked for Tokyo Metropolitan Cancer and Infectious Disease Center. He was appointed to a director of Surgery and also to a director of Clinical Trial Department. He was engaged in the care of breast cancer patients, laboratory researches and clinical trials. In 2000, he studied at Department of Breast Medical Oncology, Dana-Farber Cancer Institute of Harvard University as a Yamagiwa-Yoshida fellow. Dr. Toi has been appointed to be a visiting professor of Drug Delivery System Center, Tokyo Science University. Since 2007 Dr. Toi has been appointed to Professor of Breast Surgery at the Graduate School of Medicine, Kyoto University, Japan and Director of the Breast Cancer Unit, Kyoto University Hospital.